(21) The brethren, which are with me.--The list of those who were with St. Paul at one time or another during his imprisonment may be gathered from the Epistles to the Colossians (Colossians 4:10-15) and Philemon (Philippians 1:23-24); where see Notes. How many of these where with him at this particular time we cannot tell. They are distinguished from "all the saints"--the body of the Church in general.

Verse 21. - Salute every saint in Christ Jesus. Every saint individually - an expression of personal affection. The words, "in Christ Jesus," may be taken with "salute," as in Romans 16:22 and 1 Corinthians 16:19. It is a Christian salutation, an acknowledgment of spiritual relationship; or better, perhaps, as in numerous passages, with "saint." All saints are in Christ, members of his body, knit together into one communion and fellowship in the mystical body of Christ. It is this union with Christ which makes them saints. The brethren which are with me greet you. Observe, he calls them "brethren," though he had none like-minded with him, save only Timothy (Philippians 2:20, 21).

4:20-23 The apostle ends with praises to God. We should look upon God, under all our weakness and fears, not as an enemy, but as a Father, disposed to pity us and help us. We must give glory to God as a Father. God's grace and favour, which reconciled souls enjoy, with the whole of the graces in us, which flow from it, are all purchased for us by Christ's merit, and applied by his pleading for us; and therefore are justly called the grace of our Lord Jesus Christ.Salute every saint in Christ Jesus,.... Meaning at Philippi, whether rich or poor, lesser or greater believers, common saints, as well as the officers of the church, bishops and deacons; who were in Christ by electing grace, and as their covenant head, and representative from everlasting, and which was manifested and made known by their conversion and the effectual calling:

the brethren which are with me greet you; such as Timothy; see Philippians 2:19; and Epaphras, Marcus, Aristarchus, Demas, and Lucas; see Plm 1:23; he makes no mention of Peter anywhere, when he writes from Rome or to it, which shows he was not there then, or a bishop of that place, as the Papists say.